The hotel is located on the Vltava River, and it is only 1 km from the Old Town Square. Guests will find many historic sites to visit including Prague Castle and the Charles Bridge. They can also visit sites such as the Prague Zoo and the Botanical Gardens. The Prague Ruzyne Airport is 16 km from the Hilton Prague. Guests will find that some attractions are within walking distance and others are easy to reach with a rental car or public transportation.

The hotel has 788 rooms for guests, all of which have air conditioning. Some of the in room amenities at the Hilton Prague include cable TV, tea and coffee making facilities, in room safes, mini bars, bathrooms, and high-speed Internet access.

Guests at the Hilton Prague will be able to use the onsite health club and spa, which offers fitness machines, a climbing wall, and a squash court. The hotel also offers a massage and a variety of treatments. Guests can dine at the onsite restaurant. The hotel offers a casino as well.